Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Advances in optical manipulation and observation of neural activity have set the stage for
widespread implementation of closed-loop and activity-guided optical control of neural …

Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …

Increased fear memory generalization is associated with posttraumatic stress disorder, but
the circuit mechanisms that regulate memory specificity remain unclear. Here, we define a …

Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains
a major clinical problem largely because the underlying neural circuitry is still not known …

The mouse visual system serves as an accessible model to understand mammalian circuit
wiring. Despite rich knowledge in retinal circuits, the long-range connectivity map from …

There has never been a wholesale way of identifying neurons that are monosynaptically
connected either to some other cell group or, especially, to a single cell. The best available …

Transgenic mouse lines are characterized with Cre recombinase driven by promoters of
CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre …

Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …

Understanding the neural basis of visual perception is a long-standing fundamental goal of
neuroscience. Historically, most vision studies were carried out on humans, macaques and …