Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during
proliferation, migration, stemness and differentiation. Src is a node of several signals …

Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …

Background In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed
in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression …

Cancer is the second leading cause of death in the world and its treatment is extremely
challenging, mainly due to its complexity. Cell-Penetrating Peptides (CPPs) are peptides …

Background Glioblastoma is the most aggressive primary brain tumour and has a very poor
prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for …

The main treatment measure currently used for glioma treatment is chemotherapy; the
biological barrier of solid tumors hinders the deep penetration of nanomedicines and limits …

An increasing body of evidence has become available to reveal the synaptic and functional
integration of glioma into the brain network, facilitating tumor progression. The novel …

Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated
regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis …