The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently
altered pathways in human cancer and has a critical role in driving tumor initiation and …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent
roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo …

Yes-associated protein (YAP) is an effector of the Hippo tumor suppressor pathway. The
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …

Summary While the small GTPase Rac1 and its effectors are well-established mediators of
mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in …

Rac GTPases, small G-proteins widely implicated in tumorigenesis and metastasis,
transduce signals from tyrosine-kinase, G-protein-coupled receptors (GPCRs), and integrins …

PTEN (phosphatase and tensin homolog on chromosome 10) is a tumor suppressor whose
cellular regulation remains incompletely understood. We identified phosphatidylinositol 3, 4 …