Liver three-dimensional cellular models for high-throughput chemical testing
Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …
In vitro models for studying chronic drug-induced liver injury
MT Donato, G Gallego-Ferrer, L Tolosa - International Journal of …, 2022 - mdpi.com
Drug-induced liver injury (DILI) is a major clinical problem in terms of patient morbidity and
mortality, cost to healthcare systems and failure of the development of new drugs. The need …
mortality, cost to healthcare systems and failure of the development of new drugs. The need …
Mimicking native liver lobule microarchitecture in vitro with parenchymal and non-parenchymal cells using 3D bioprinting for drug toxicity and drug screening …
Bioengineering an in vitro liver model recapitulating the native liver microarchitecture
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …
Organoid technology: A reliable developmental biology tool for organ-specific nanotoxicity evaluation
Engineered nanomaterials are bestowed with certain inherent physicochemical properties
unlike their parent materials, rendering them suitable for the multifaceted needs of state-of …
unlike their parent materials, rendering them suitable for the multifaceted needs of state-of …
3D human liver spheroids for translational pharmacology and toxicology
M Ingelman‐Sundberg… - Basic & clinical …, 2022 - Wiley Online Library
Drug development is a failure‐prone endeavour, and more than 85% of drugs fail during
clinical development, showcasing that current preclinical systems for compound selection …
clinical development, showcasing that current preclinical systems for compound selection …
Modeling drug-induced liver injury: current status and future prospects
DE Di Zeo-Sánchez, A Segovia-Zafra… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable
multifactorial condition. At present, validated preclinical models for the prediction of the …
multifactorial condition. At present, validated preclinical models for the prediction of the …
Applied hepatic bioengineering: Modeling the human liver using organoid and liver-on-a-chip technologies
The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-
clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …
clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …
A pumpless liver-on-a-chip for drug hepatotoxicity analysis
D Jiao, L Xie, W Xing - Analyst, 2024 - pubs.rsc.org
This study presents the development and validation of an innovative microfluidic liver-on-a-
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …
Human three-dimensional hepatic models: cell type variety and corresponding applications
Q Xu - Frontiers in Bioengineering and Biotechnology, 2021 - frontiersin.org
Owing to retained hepatic phenotypes and functions, human three-dimensional (3D) hepatic
models established with diverse hepatic cell types are thought to recoup the gaps in drug …
models established with diverse hepatic cell types are thought to recoup the gaps in drug …
A microfluidic thyroid-liver platform to assess chemical safety in humans
J Kühnlenz, D Karwelat, T Steger-Hartmann… - ALTEX-Alternatives to …, 2023 - altex.org
Thyroid hormones (THs) are crucial regulators of human metabolism and early
development. During the safety assessment of plant protection products, the human …
development. During the safety assessment of plant protection products, the human …