Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

Drug-induced liver injury (DILI) is a major clinical problem in terms of patient morbidity and
mortality, cost to healthcare systems and failure of the development of new drugs. The need …

Bioengineering an in vitro liver model recapitulating the native liver microarchitecture
consisting of parenchymal and non-parenchymal cells is crucial in achieving cellular …

Engineered nanomaterials are bestowed with certain inherent physicochemical properties
unlike their parent materials, rendering them suitable for the multifaceted needs of state-of …

Drug development is a failure‐prone endeavour, and more than 85% of drugs fail during
clinical development, showcasing that current preclinical systems for compound selection …

Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable
multifactorial condition. At present, validated preclinical models for the prediction of the …

The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-
clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …

This study presents the development and validation of an innovative microfluidic liver-on-a-
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …

Owing to retained hepatic phenotypes and functions, human three-dimensional (3D) hepatic
models established with diverse hepatic cell types are thought to recoup the gaps in drug …

Thyroid hormones (THs) are crucial regulators of human metabolism and early
development. During the safety assessment of plant protection products, the human …