Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder
AM Tartaglione, S Schiavi, G Calamandrei, V Trezza - Neuropharmacology, 2019 - Elsevier
Impairments in social interaction and verbal and non verbal communication are among the
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …
[HTML][HTML] Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders
J Gruchot, F Herrero, U Weber-Stadlbauer… - Brain, Behavior, and …, 2023 - Elsevier
Human endogenous retroviruses (ERVs) are ancestorial retroviral elements that were
integrated into our genome through germline infections and insertions during evolution …
integrated into our genome through germline infections and insertions during evolution …
Human endogenous retroviruses role in cancer cell stemness
C Matteucci, E Balestrieri, A Argaw-Denboba… - Seminars in cancer …, 2018 - Elsevier
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …
critical issues of oncological diseases. In this scenario, increasing scientific evidences …
Retrotransposon-induced mosaicism in the neural genome
GO Bodea, EGZ McKelvey, GJ Faulkner - Open Biology, 2018 - royalsocietypublishing.org
Over the past decade, major discoveries in retrotransposon biology have depicted the
neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 …
neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 …
[HTML][HTML] Type W human endogenous retrovirus (HERV-W) integrations and their mobilization by L1 machinery: contribution to the human transcriptome and impact on …
N Grandi, E Tramontano - Viruses, 2017 - mdpi.com
Human Endogenous Retroviruses (HERVs) are ancient infection relics constituting~ 8% of
our DNA. While HERVs' genomic characterization is still ongoing, impressive amounts of …
our DNA. While HERVs' genomic characterization is still ongoing, impressive amounts of …
[HTML][HTML] Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster
BI Crawford, MJ Talley, J Russman, J Riddle… - Nature …, 2024 - nature.com
Neural stem and progenitor cell (NSPC) maintenance is essential for ensuring that
organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in …
organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in …
[HTML][HTML] Endogenous retroviruses in nervous system disorders
V Gröger, A Emmer, MS Staege, H Cynis - Pharmaceuticals, 2021 - mdpi.com
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of
several nervous system disorders including multiple sclerosis and amyotrophic lateral …
several nervous system disorders including multiple sclerosis and amyotrophic lateral …
[HTML][HTML] Children with autism spectrum disorder and their mothers share abnormal expression of selected endogenous retroviruses families and cytokines
The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental
disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is …
disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is …
[HTML][HTML] HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
A Argaw-Denboba, E Balestrieri, A Serafino… - Journal of experimental …, 2017 - Springer
Background Melanoma is a heterogeneous tumor in which phenotype-switching and CD133
marker have been associated with metastasis promotion and chemotherapy resistance …
marker have been associated with metastasis promotion and chemotherapy resistance …
Transposable elements in brain health and disease
A Ahmadi, I De Toma, N Vilor-Tejedor… - Ageing research …, 2020 - Elsevier
Transposable elements (TEs) occupy a large fraction of the human genome but only a small
proportion of these elements are still active today. Recent works have suggested that TEs …
proportion of these elements are still active today. Recent works have suggested that TEs …