Alphaviruses are positive-strand RNA viruses, typically transmitted by mosquitoes between
vertebrate hosts. They encode four essential replication proteins, the non-structural proteins …

Structural genomics involves the advent of three-dimensional structures of the genome
encoded proteins through various techniques available. Numerous structural genomics …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Many viruses encode RNA-modifying enzymes to edit the 5′ end of viral RNA to mimic the
cellular mRNA for effective protein translation, genome replication, and evasion of the host …

Chikungunya virus is a re-emerging arbovirus that has caused epidemic outbreaks in recent
decades. Patients in older age groups with high viral load and severe immunologic …

Many alphaviruses, including chikungunya virus (CHIKV) are known human pathogens that
lack specific and effective antivirals or vaccines available. The upstream portion of the …

Ross River virus (RRV) and Barmah Forest virus (BFV) are arthritogenic arthropod-borne
viruses (arboviruses) that exhibit generalist host associations and share distributions in …

In this era spanning more than 60 years (from the early 1960s till today (2023), a broad
variety of actors played a decisive role: Piet De Somer, Tom C. Merigan, Paul A. Janssen …

Chikungunya is a re-emerging viral infection of worldwide concern, and new antiviral
therapeutics are necessary to combat this disease. Inhibitors of the non-structural protein 1 …

Usutu virus (USUV), is a mosquito-borne flavivirus currently spreading outside the African
continent producing substantial avian mortality. In contrast, infected humans could exhibit …