Ketamine produces immediate antidepressant effects and has inspired research into next-
generation treatments. Ketamine also has short term dissociative effects, in which …

Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …

Ketamine improves motivation-related symptoms in depression but simultaneously elicits
similar symptoms in healthy individuals, suggesting that it might have different effects in …

Ketamine commonly and rapidly induces dissociative and other altered states of
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …

The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …

N-methyl-d-aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide,
are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of …

Conventional monoamine-based pharmacotherapy, considered the first-line treatment for
major depressive disorder (MDD), has several challenges, including high rates of non …

Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting
antidepressant effects in patients with major depressive disorder unresponsive to standard …

For the past decade, ketamine, an N-methyl-D-aspartate receptor (NMDAr) antagonist, has
been considered a promising treatment for major depressive disorder (MDD). Unlike the …

Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive
range of treatment options, about a third of patients still struggle to respond to available …