The role of dissociation in ketamine's antidepressant effects
ED Ballard, CA Zarate Jr - Nature communications, 2020 - nature.com
Ketamine produces immediate antidepressant effects and has inspired research into next-
generation treatments. Ketamine also has short term dissociative effects, in which …
generation treatments. Ketamine also has short term dissociative effects, in which …
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …
medicine as an important anesthetic with many uses. More recently, ketamine has been …
Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals
Ketamine improves motivation-related symptoms in depression but simultaneously elicits
similar symptoms in healthy individuals, suggesting that it might have different effects in …
similar symptoms in healthy individuals, suggesting that it might have different effects in …
Ketamine's acute effects on negative brain states are mediated through distinct altered states of consciousness in humans
Ketamine commonly and rapidly induces dissociative and other altered states of
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …
Ketamine in neuropsychiatric disorders: an update
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents
MC Kalmoe, AM Janski, CF Zorumski, P Nagele… - Journal of the …, 2020 - Elsevier
N-methyl-d-aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide,
are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of …
are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of …
Intrinsic connectivity networks of glutamate-mediated antidepressant response: a neuroimaging review
Conventional monoamine-based pharmacotherapy, considered the first-line treatment for
major depressive disorder (MDD), has several challenges, including high rates of non …
major depressive disorder (MDD), has several challenges, including high rates of non …
Modulation of amygdala reactivity following rapidly acting interventions for major depression
JRA Loureiro, A Leaver, M Vasavada… - Human Brain …, 2020 - Wiley Online Library
Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting
antidepressant effects in patients with major depressive disorder unresponsive to standard …
antidepressant effects in patients with major depressive disorder unresponsive to standard …
[HTML][HTML] Storm on predictive brain: a neurocomputational account of ketamine antidepressant effect
H Bottemanne, L Berkovitch, C Gauld… - Neuroscience & …, 2023 - Elsevier
For the past decade, ketamine, an N-methyl-D-aspartate receptor (NMDAr) antagonist, has
been considered a promising treatment for major depressive disorder (MDD). Unlike the …
been considered a promising treatment for major depressive disorder (MDD). Unlike the …
[HTML][HTML] Neuroimaging-derived biomarkers of the antidepressant effects of ketamine
A Zavaliangos-Petropulu, NB Al-Sharif, B Taraku… - Biological psychiatry …, 2023 - Elsevier
Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive
range of treatment options, about a third of patients still struggle to respond to available …
range of treatment options, about a third of patients still struggle to respond to available …