Urogenital tuberculosis—epidemiology, pathogenesis and clinical features

A Muneer, B Macrae, S Krishnamoorthy… - Nature Reviews …, 2019 - nature.com
Tuberculosis (TB) is the most common cause of death from infectious disease worldwide. A
substantial proportion of patients presenting with extrapulmonary TB have urogenital TB (UG …

Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice

RS Wallis, M Pai, D Menzies, TM Doherty, G Walzl… - The lancet, 2010 - thelancet.com
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

CRISPR detection of circulating cell-free Mycobacterium tuberculosis DNA in adults and children, including children with HIV: a molecular diagnostics study

Z Huang, SM LaCourse, AW Kay, J Stern… - The Lancet …, 2022 - thelancet.com
Background Tuberculosis remains a leading cause of global mortality, especially for adults
and children living with HIV (CLHIV) underdiagnosed by sputum-based assays. Non-sputum …

Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease

D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities

R McNerney, M Maeurer, I Abubakar… - Journal of Infectious …, 2012 - academic.oup.com
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid
point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to …

Diagnosis of extrapulmonary tuberculosis by PCR

PK Mehta, A Raj, N Singh… - FEMS Immunology & …, 2012 - academic.oup.com
During the last two decades, the resurgence of tuberculosis (TB) has been documented in
both developed and developing nations, and much of this increase in TB burden coincided …

TBscreen: A passive cough classifier for tuberculosis screening with a controlled dataset

M Sharma, V Nduba, LN Njagi, W Murithi… - Science …, 2024 - science.org
Recent respiratory disease screening studies suggest promising performance of cough
classifiers, but potential biases in model training and dataset quality preclude robust …

New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects

MP Nicol, HJ Zar - Paediatric respiratory reviews, 2011 - Elsevier
Childhood pulmonary TB (PTB) is under diagnosed, in part due to difficulties in obtaining
microbiological confirmation. However, given the poor specificity of clinical diagnosis …

Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13

SG Thakku, J Lirette, K Murugesan, J Chen… - Nature …, 2023 - nature.com
Detection of microbial cell-free DNA (cfDNA) circulating in the bloodstream has emerged as
a promising new approach for diagnosing infection. Microbial diagnostics based on cfDNA …

[HTML][HTML] Diagnosing infections—current and anticipated technologies for point-of-care diagnostics and home-based testing

L Bissonnette, MG Bergeron - Clinical Microbiology and Infection, 2010 - Elsevier
In recent years, we have witnessed many transitions in healthcare systems around the
globe. For example, population expansion and ageing, and the human immunodeficiency …