Aliphatic polycarbonates have gained increased attention as biomaterials largely owing to
their biocompatibility and tunable degradation. Moreover, the ability to introduce functional …

Magnetic nanoparticles in general, and iron oxide nanoparticles in particular, have been
studied extensively during the past 20 years for numerous biomedical applications. The …

For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Aliphatic polycarbonates have drawn attention as biodegradable polymers that can be
applied to a broad range of resorbable medical devices. In particular, poly (trimethylene …

A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …

Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can
mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano …

Despite that great progression has been made in nanoparticulate drug delivery systems
(nano-DDS), multiple drug delivery dilemmas still impair the delivery efficiency of …

Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …

The blood brain barrier (BBB) offers protection to the central nervous system (CNS) by
maintaining homeostasis. Besides restricting the entry of harmful xenobiotics and …

The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …