One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development,
including infertility. It is of importance to summarize the current evidence regarding the …

Exposure of oocytes to specific amino acids during in vitro fertilisation (IVF) improves
preimplantation embryo development. Embryos fertilised in medium with proline and its …

Mammalian developmental timing is adjustable in vivo by preserving pre-implantation
embryos in a dormant state called diapause. Inhibition of the growth regulator mTOR …

The role of the insulin-like growth factor (IGF) system has attracted close attention. The
activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to …

Reproducing the environment to which the embryo is naturally exposed may be an
alternative to improve viability of embryos produced in vitro. In the first part of this work, we …

Purpose Estrogen is well-known for preparing uterine receptivity. However, its roles in
regulating embryo development and implantation are unclear. Our objective was to …

Chemically defined oocyte maturation media supplemented with FGF2, LIF, and IGF-1 (FLI
medium) enabled significantly improved oocyte quality in multiple farm animals, yet the …

Simple Summary Routine embryo production is the cornerstone for several research topics
such as assisted reproduction techniques. For this, suitable culture media are needed to …

Profiling bovine blastocyst transcriptome at the single-cell level has enabled us to reveal the
first cell lineage segregation, during which the inner cell mass (ICM), trophectoderm (TE) …

Obese women are subfertile and have reduced assisted reproduction success, which may
be due to reduced oocyte competence. We hypothesize that consumption of a high-fat/high …