A developmental ontology for the mammalian brain based on the prosomeric model

L Puelles, M Harrison, G Paxinos, C Watson - Trends in neurosciences, 2013 - cell.com
In the past, attempts to create a hierarchical classification of brain structures (an ontology)
have been limited by the lack of adequate data on developmental processes. Recent studies …

Concept of neural genoarchitecture and its genomic fundament

L Puelles, JL Ferran - Frontiers in neuroanatomy, 2012 - frontiersin.org
The recent concept of neural genoarchitecture (or genoarchitectonics) is examined from
several angles, aiming to clarify the rationale for this new approach in causal and descriptive …

De novo mutations in PLXND1 and REV3L cause Möbius syndrome

L Tomas-Roca, A Tsaalbi-Shtylik, JG Jansen… - Nature …, 2015 - nature.com
Möbius syndrome (MBS) is a neurological disorder that is characterized by paralysis of the
facial nerves and variable other congenital anomalies. The aetiology of this syndrome has …

Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains

A Alonso, P Merchán, JE Sandoval… - Brain structure and …, 2013 - Springer
The raphe nuclei represent the origin of central serotonergic projections. The literature
distinguishes seven nuclei grouped into rostral and caudal clusters relative to the pons. The …

Time for radical changes in brain stem nomenclature—applying the lessons from developmental gene patterns

C Watson, C Bartholomaeus, L Puelles - Frontiers in neuroanatomy, 2019 - frontiersin.org
The traditional subdivision of the brain stem into midbrain, pons, and medulla oblongata is
based purely on the external appearance of the human brain stem. There is an urgent need …

Mouse Fgf8‐Cre‐LacZ lineage analysis defines the territory of the postnatal mammalian isthmus

C Watson, T Shimogori, L Puelles - Journal of Comparative …, 2017 - Wiley Online Library
The isthmus is recognized as the most rostral segment of the hindbrain in non‐mammalian
vertebrates. In mammalian embryos, transient Fgf8 expression defines the developing …

Plan of the developing vertebrate nervous system

L Puelles - Pattering and Cell Type Specification in the …, 2013 - books.google.com
This chapter on the fundamental organization of the brain of vertebrates will be based
straightforwardly upon the prosomeric model. Discussion of earlier influential models which …

Segmental arithmetic: summing up the Hox gene regulatory network for hindbrain development in chordates

HJ Parker, R Krumlauf - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
Organization and development of the early vertebrate hindbrain are controlled by a cascade
of regulatory interactions that govern the process of segmentation and patterning along the …

[HTML][HTML] Recollections on the origins and development of the prosomeric model

L Puelles - Frontiers in Neuroanatomy, 2021 - frontiersin.org
The prosomeric model was postulated jointly by L. Puelles and JLR Rubenstein in 1993 and
has been developed since by means of minor changes and a major update in 2012. This …

Molecular organization and patterning of the medulla oblongata in health and disease

D Diek, MP Smidt, S Mesman - International Journal of Molecular …, 2022 - mdpi.com
The medulla oblongata, located in the hindbrain between the pons and the spinal cord, is an
important relay center for critical sensory, proprioceptive, and motoric information. It is an …