This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

Staphylococcus aureus is a major opportunistic human pathogen that frequently causes
disease in community and hospital settings. Nasal colonization is an important risk factor for …

Mannan-binding lectin (MBL) deficiency has been classified as a commonly occurring
immune disorder, affecting approximately 30% of the human population. MBL, being part of …

Summary The Lyme disease agent Borrelia burgdorferi is primarily transmitted to vertebrates
by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Introduction While complement is a contributor to disease severity in severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement …

Although some evidence showed the activation of complement systems in COVID-19
patients, proinflammatory status and lectin pathway remain unclear. Thus, the present study …

Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that
kills a wide range of pathogenic microbes through complement activation. A substantial …