Recent Advances on the Chemistry of GABAB Receptor Allosteric Modulators
C Mugnaini, F Corelli - GABAB Receptor, 2024 - Springer
Allosteric modulation of therapeutic protein targets has been proposed as a possible
strategy to overcome the limitations of orthosteric ligands. However, it has been shown that …
strategy to overcome the limitations of orthosteric ligands. However, it has been shown that …
Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant
M Minere, M Mortensen, V Dorovykh, G Warnes… - Brain, 2024 - academic.oup.com
GABABRs are key membrane proteins that continually adapt the excitability of the nervous
system. These G-protein coupled receptors are activated by the brain's premier inhibitory …
system. These G-protein coupled receptors are activated by the brain's premier inhibitory …
Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Alcohol Use Disorder
P Maccioni, G Colombo - GABA - Springer
To date, ten different positive allosteric modulators (PAMs) of the GABAB receptor have
been tested in laboratory rodents for their suppressing effects on a series of alcohol-related …
been tested in laboratory rodents for their suppressing effects on a series of alcohol-related …