Remarkable progress has been made in islet transplantation over a span of 40 years. Once
just an experimental curiosity in mice, this therapy has moved forward, and can now provide …

Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since
insulin is released by the islets of Langerhans, obtaining viable and functional islets is …

Background. The optimal enzyme blend that maximizes human islet yield for transplantation
remains to be determined. In this study, we evaluated eight different enzyme combinations …

The autoimmune response that characterizes type 1 diabetes (T1D) has no clear cause.
Extracellular vesicles (EVs) play an important role in triggering the immune response in …

Despite modern medical breakthroughs, diabetes mellitus is a worldwide leading cause of
morbidity and mortality. Definitive surgical treatment of diabetes mellitus was established …

Abstract Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the
mechanisms by which autoreactive responses are generated in susceptible individuals are …

Type 1 diabetes (T1D) has been determined to be an autoimmune disease involving the
selective destruction of insulin-producing β-cells in the pancreatic islets of Langerhans that …

In comparison to procedures used for the separation of individual cell types from other
organs, the process of human pancreatic islet isolation aims to digest the pancreatic …

The choice of enzyme blend is critical for successful islet isolation. Islet yield, viability,
integrity, and function are important factors that influence the outcome of islet …

Collagenases are critical reagents determining yield and quality of isolated human
pancreatic islets and may affect islet transplantation outcome. Some islet transplantation …