The high-throughput-next generation sequencing (HT-NGS) technologies are currently the
hottest topic in the field of human and animals genomics researches, which can produce …

If one accepts that the fundamental pursuit of genetics is to determine the genotypes that
explain phenotypes, the meteoric increase of DNA sequence information applied toward that …

While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian
transcriptome, their biological functions has remained elusive. A few long ncRNAs that have …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The Nrf2 (nuclear factor E2 p45-related factor 2) transcription factor responds to diverse
oxidative and electrophilic environmental stresses by circumventing repression by Keap1 …

We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin
immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA …

Much attention has focused on a small set of transcription factors that maintain human or
mouse embryonic stem (ES) cells in a pluripotent state. To gain a more complete …

Long non-coding (lnc) RNAs can regulate gene expression and protein functions. However,
the proportion of lncRNAs with biological activities among the thousands expressed in …

Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible
isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different …

Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which
PPARγ and members of the C/EBP family are key players. Here we review the roles of …