Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …

Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …

Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information
from the retina to the brain. Diverse insults and pathological states cause degeneration of …

Many distinct signaling pathways allow the cell to receive, process, and respond to
information. Often, components of different pathways interact, resulting in signaling …

▪ Abstract Highly enriched in brain tissue and present throughout the body, Ca2+/calmodulin-
dependent protein kinase II (CaMKII) is central to the coordination and execution of Ca2+ …

Multifunctional calcium-calmodulin-dependent protein kinase (CaM kinase) transduces
transient elevations in intracellular calcium into changes in the phosphorylation state and …

Ca2+/calmodulin (CaM)-dependent protein kinase (CaMKII) is a ubiquitous mediator of
Ca2+-linked signalling that phosphorylates a wide range of substrates to co-ordinate and …

Publisher Summary This chapter presents a table of phosphorylation site sequences for
protein-serine/threonine and protein-tyrosine kinases. Over 240 phosphorylation site …

Learning and memory require the formation of new neural networks in the brain. A key
mechanism underlying this process is synaptic plasticity at excitatory synapses, which …

Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) is localized in the
postsynaptic density (PSD) and is necessary for LTP induction. Much has been learned …