The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

Anionic phospholipids, which include phosphatidic acid, phosphatidylserine, and
phosphoinositides, represent a small percentage of membrane lipids. They are able to …

During macroautophagic stress, autophagosomes can be produced continuously and in
high numbers. Many different organelles have been reported as potential donor membranes …

Mutations in the human VPS13 genes are responsible for neurodevelopmental and
neurodegenerative disorders including chorea acanthocytosis (VPS13A) and Parkinson's …

In eukaryotic cells, mitochondria are closely tethered to the endoplasmic reticulum (ER) at
sites called mitochondria‐associated ER membranes (MAMs). Ca2+ ion and phospholipid …

INTRODUCTION Insulin is secreted by pancreatic β cells in response to glucose stimulation.
Its release is controlled by the interplay of calcium and phosphoinositide signaling …

Transfer of lipid across the cytoplasm is an essential process for intracellular lipid traffic.
Lipid transfer proteins (LTPs) are defined by highly controlled in vitro experiments. The …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

Contact sites are places where two organelles join together to carry out a shared activity
requiring nonvesicular communication. A large number of contact sites have been …