[HTML][HTML] Cell death in liver diseases: a review
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
[HTML][HTML] Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury
H Jaeschke, A Ramachandran - Annual Review of Pathology …, 2024 - annualreviews.org
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …
western countries, and, because of translational relevance of animal models, APAP is …
[HTML][HTML] Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
M Yan, Y Huo, S Yin, H Hu - Redox biology, 2018 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …
many developed countries. Mitochondrial oxidative stress is considered to be the …
[PDF][PDF] Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis
G Farrell, JM Schattenberg, I Leclercq, MM Yeh… - …, 2019 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …
factors and genetic determinants that cannot be completely replicated in animals …
Cell death and cell death responses in liver disease: mechanisms and clinical relevance
Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity
CI Ghanem, MJ Pérez, JE Manautou… - Pharmacological …, 2016 - Elsevier
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication …
be safe when administered within its therapeutic range, but in cases of acute intoxication …
[HTML][HTML] Decoding cell death signals in liver inflammation
Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
MR McGill, H Jaeschke - Pharmaceutical research, 2013 - Springer
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …
[HTML][HTML] Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis
A Iorga, L Dara, N Kaplowitz - International journal of molecular sciences, 2017 - mdpi.com
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
H Jaeschke, MR McGill… - Drug metabolism …, 2012 - Taylor & Francis
Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …
established drugs. For example, acetaminophen overdose is currently the most frequent …