There is a wide body of evidence to suggest the existence of at least three distinct opioid
receptor types in the CNS, referred to as~, 6, and K. This paper reviews some of the findings …

The role of peptides as signalling molecules in the nervous system has been studied for
more than 30 years. Neuropeptides and their G-protein-coupled receptors are widely …

The nucleotide sequence of a 1,091-base pair cloned cDNA insert encoding bovine
corticotropin-β-lipotropin precursor mRNA is reported. The corresponding amino acid …

The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from
human phaeochromocytoma is reported. The corresponding amino acid sequence shows …

Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as
the opioid peptide enkephalins, neurotensin, and substance P, were first isolated from the …

The hypothalamic-pituitary-adrenal (HPA) axis is central to homeostasis, stress responses,
energy metabolism, and neuropsychiatric function. The history of this complex system …

Opiomelanotropinergic cells in the intermediate lobe of the pituitary and in neurons in the
brain secrete at least 7 peptides related to melanocyte stimulating hormone (MSH) and β …

Extensive evidence has indicated that distinct neural systems specifically designed to inhibit
sensitivity to painful stimuli exist. Recent advances suggest that the endorphins, enkephalins …

The distribution of peptide-containing neurons in the oesophagus, stomach and small and
large intestine of the rat and the guinea-pig has been studied with the indirect …

A comparison of the structures of a precursor of trigramin (a disintegrin), metalloproteinases,
disintegrins and related proteins, suggests the existence of common precursors for …