Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid
mediators endocannabinoids present in virtually all tissues, their G-protein-coupled …

The question of how the neural and immune systems interact in host defense is important,
integrating a system that senses the whole body with one that protects. Understanding the …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

Skin is innervated by a multitude of sensory nerves that are important to the function of this
barrier tissue in homeostasis and injury. The role of innervation and neuromediators has …

Sensitive skin is a clinical condition defined by the self‐reported facial presence of different
sensory perceptions, including tightness, stinging, burning, tingling, pain and pruritus …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory
neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids …

The ion channel TRPV1 is involved in a wide range of processes including nociception,
thermosensation and, more recently discovered, energy homeostasis. Tightly controlling …

In the skin, cannabinoid lipids, whether of endogenous or exogenous origin, are capable of
regulating numerous sensory, homeostatic, and inflammatory events. Although many of …