Accelerated development of colloidal nanomaterials enabled by modular microfluidic reactors: toward autonomous robotic experimentation

AA Volk, RW Epps, M Abolhasani - Advanced Materials, 2021 - Wiley Online Library
In recent years, microfluidic technologies have emerged as a powerful approach for the
advanced synthesis and rapid optimization of various solution‐processed nanomaterials …

Flow chemistry: a sustainable voyage through the chemical universe en route to smart manufacturing

AA Volk, ZS Campbell, MYS Ibrahim… - Annual Review of …, 2022 - annualreviews.org
Microfluidic devices and systems have entered many areas of chemical engineering, and
the rate of their adoption is only increasing. As we approach and adapt to the critical global …

Dynamic light scattering (DLS) principles, perspectives, applications to biological samples

S Falke, C Betzel - Radiation in bioanalysis: Spectroscopic techniques …, 2019 - Springer
Focus a laser on dissolved particles and analyze the scattered light to reveal their size. This
well established principle is used in dynamic light scattering (DLS), or also called photon …

Automation and miniaturization: enabling tools for fast, high‐throughput process development in integrated continuous biomanufacturing

TC Silva, M Eppink, M Ottens - Journal of Chemical …, 2022 - Wiley Online Library
Process development in the biotech industry leads to investments around hundred of
millions of dollars. It is important to mitigate costs without neglecting the quality of process …

Combining microfluidics and FT-IR spectroscopy: towards spatially resolved information on chemical processes

A Perro, G Lebourdon, S Henry, S Lecomte… - Reaction Chemistry & …, 2016 - pubs.rsc.org
This review outlines the combination of infrared spectroscopy and continuous microfluidic
processes. FTIR spectroscopy gives access to the microscopic chemical composition of …

Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing

MN São Pedro, ME Klijn, MHM Eppink… - Journal of Chemical …, 2022 - Wiley Online Library
The transition to continuous biomanufacturing is considered the next step to reduce costs
and improve process robustness in the biopharmaceutical industry, while also improving …

Transfersomal nanoparticles for enhanced transdermal delivery of clindamycin

AAH Abdellatif, HM Tawfeek - Aaps Pharmscitech, 2016 - Springer
The aim of this work was to study the potential of delivering clindamycin phosphate, as an
efficient antibiotic drug, into a more absorbed, elastic ultradeformable form, transfersomes …

Microfluidic in-line dynamic light scattering with a commercial fibre optic system

LMG Torquato, N Hélaine, Y Cui, R O'Connell… - Lab on a Chip, 2023 - pubs.rsc.org
We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free
fibre-optic system, enabling the under-flow characterisation of a range of solutions …

Early stage kinetics of polyelectrolyte complex coacervation monitored through stopped-flow light scattering

X Liu, M Haddou, I Grillo, Z Mana, JP Chapel, C Schatz - Soft Matter, 2016 - pubs.rsc.org
Polyelectrolyte complexes (PECs) between poly (acrylic acid)(PAA) and poly (
diallyldimethylammonium chloride)(PDADMAC), a model system forming coacervate …

A Dual-angle fiber dynamic light scattering system integrated with microfluidic chip for particle size measurement

M Chen, Y Wang, W Li, M Xia, Z Meng, L Xia - Optics & Laser Technology, 2022 - Elsevier
Dynamic light scattering (DLS) is an effective tool for measuring the distribution of the size of
particles. In this work, we design a novel integrated dual-angle DLS prototype which …