Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Viral myocarditis remains a prominent infectious-inflammatory disease for patients
throughout the lifespan. The condition presents several challenges including varied modes …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Basal autophagy is a crucial mechanism in cellular homeostasis, underlying both normal
cellular recycling and the clearance of damaged or misfolded proteins, organelles and …

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By
linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF …

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart? | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

The autosomal dominant mutation in the human αB-crystallin gene inducing a R120G amino
acid exchange causes a multisystem, protein aggregation disease including …

Proteasome inhibitors (PIs) are the backbone of combination treatments for patients with
multiple myeloma and AL amyloidosis, while also indicated in Waldenström's …