Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous
antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as …

Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …

2 Weiss et al Potassium and Arrhythmias subthreshold EADs, thereby initiating reentry
(Figure 3, black arrows). Under these conditions, reentry can have a special property called …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Drug-induced long QT syndrome (diLQTS) and congenital LQTS (cLQTS) share many
features, and both syndromes can result in life-threatening torsades de pointes (TdP). Our …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for
assessment of drug-induced arrhythmias and are being considered for use under the …

Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple
other conditions can occasionally produce exaggerated prolongation of the QT interval on …

Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse
drug effects. Numerous drugs have been shown to have the potential to induce lethal …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Significant advances in cancer treatment have resulted in decreased cancer related
mortality for many malignancies with some cancer types now considered chronic diseases …