Cancer statistics in 2018 highlight an 8.6 million incidence in female cancers, and 4.2 million
cancer deaths globally. Moreover, breast cancer is the most frequent malignancy in females …

The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …

Cancer remains the leading cause of death worldwide despite the enormous efforts that are
made in the development of cancer biology and anticancer therapeutic treatment …

Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late
clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of …

Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the
underlying mechanisms are still poorly understood. Understanding the breast cancer …

More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …

Background TP53 is one of the most frequently mutated genes among all cancer types, and
TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there …

Metastatic breast cancer (MBC) is typically an incurable disease with high mortality rates;
thus, early identification of metastatic features and disease recurrence through precise …

Abstract Epithelial‑mesenchymal transition (EMT), during which cancer cells lose the
epithelial phenotype and gain the mesenchymal phenotype, has been verified to result in …

Triple negative breast cancer (TNBC), characterized by its highly aggressive and metastatic
features, is associated with poor prognosis and high mortality partly due to lack of effective …