The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

DP Veitch, MW Weiner, M Miller, PS Aisen… - Alzheimer's & …, 2024 - Wiley Online Library
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve
Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging …

[PDF][PDF] Neurosymbolic ai for reasoning on graph structures: A survey

LN Delong, RF Mir, M Whyte, Z Ji… - arXiv preprint arXiv …, 2023 - researchgate.net
Neurosymbolic AI is an increasingly active area of research which aims to combine symbolic
reasoning methods with deep learning to generate models with both high predictive …

[HTML][HTML] Semantic harmonization of Alzheimer's disease datasets using AD-Mapper

P Wegner, H Balabin, MC Ay… - Journal of …, 2023 - content.iospress.com
Background: Despite numerous past endeavors for the semantic harmonization of
Alzheimer's disease (AD) cohort studies, an automatic tool has yet to be developed …

[HTML][HTML] An ontology-based approach for harmonization and cross-cohort query of Alzheimer's disease data resources

X Hao, X Li, GQ Zhang, C Tao, PE Schulz… - BMC Medical Informatics …, 2023 - Springer
Abstract Background In the United States, the National Alzheimer's Coordinating Center
(NACC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) are two major data …

[HTML][HTML] Generation of realistic synthetic data using multimodal neural ordinary differential equations

P Wendland, C Birkenbihl, M Gomez-Freixa… - NPJ Digital …, 2022 - nature.com
Individual organizations, such as hospitals, pharmaceutical companies, and health
insurance providers, are currently limited in their ability to collect data that are fully …

[HTML][HTML] psHarmonize: Facilitating reproducible large-scale pre-statistical data harmonization and documentation in R

JJ Stephen, P Carolan, AE Krefman, S Sedaghat… - Patterns, 2024 - cell.com
Combining pertinent data from multiple studies can increase the robustness of
epidemiological investigations. Effective" pre-statistical" data harmonization is paramount to …

Neurosymbolic AI for Reasoning Over Knowledge Graphs: A Survey

LN DeLong, RF Mir, JD Fleuriot - IEEE Transactions on Neural …, 2024 - ieeexplore.ieee.org
Neurosymbolic artificial intelligence (AI) is an increasingly active area of research that
combines symbolic reasoning methods with deep learning to leverage their complementary …

[HTML][HTML] Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer's disease

S Golriz Khatami, Y Salimi, M Hofmann-Apitius… - Alzheimer's Research & …, 2022 - Springer
Abstract Background Previous models of Alzheimer's disease (AD) progression were
primarily hypothetical or based on data originating from single cohort studies. However …

Deep learning-based patient stratification for prognostic enrichment of clinical dementia trials

C Birkenbihl, J de Jong, I Yalchyk, H Froehlich - medRxiv, 2023 - medrxiv.org
Dementia probably due to Alzheimer's disease (AD) is a progressive condition that
manifests in cognitive decline and impairs patients' daily life. Affected patients show great …

Simulation-based power analysis could improve the design of clinical trials in Alzheimer's disease

D Andrews, DL Arnold, D Bzdok, S Ducharme… - medRxiv, 2022 - medrxiv.org
Clinical trials of new treatments in different progressive diseases use power analysis to
determine the sample size needed for a trial to obtain a statistically significant estimate for …