Incorporating Intracellular Processes in Virus Dynamics Models

SM Ciupe, JM Conway - Microorganisms, 2024 - mdpi.com
In-host models have been essential for understanding the dynamics of virus infection inside
an infected individual. When used together with biological data, they provide insight into …

Molecular mechanism matters: Benefits of mechanistic computational models for drug development

LE Clegg, F Mac Gabhann - Pharmacological research, 2015 - Elsevier
Making drug development a more efficient and cost-effective process will have a
transformative effect on human health. A key, yet underutilized, tool to aid in this …

Modeling the immune response to HIV infection

JM Conway, RM Ribeiro - Current opinion in systems biology, 2018 - Elsevier
The interplay between immune response and HIV is intensely studied via mathematical
modeling, with significant insights but few direct answers. In this short review, we highlight …

Лимфомы у ВИЧ-инфицированных больных: обзор литературы

АВ Пивник, МВ Туманова, НВ Серегин… - Клиническая …, 2014 - cyberleninka.ru
В обзоре изложены материалы статей зарубежных и отечественных авторов по
частоте, патогенезу, диагностике и лечению злокачественных …

A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

GW Suryawanshi, A Hoffmann - Journal of theoretical biology, 2015 - Elsevier
Abstract Human immunodeficiency virus-1 (HIV-1) employs accessory proteins to evade
innate immune responses by neutralizing the anti-viral activity of host restriction factors …

Viral subversion of APOBEC3s: lessons for anti-tumor immunity and tumor immunotherapy

F Borzooee, M Asgharpour, E Quinlan… - International Reviews …, 2018 - Taylor & Francis
ABSTRACT APOBEC3s (A3) are endogenous DNA-editing enzymes that are expressed in
immune cells including T lymphocytes. A3s target and mutate the genomes of retroviruses …

Mechanistic models predict efficacy of CCR5‐deficient stem cell transplants in HIV patient populations

I Hosseini, FM Gabhann - CPT: pharmacometrics & systems …, 2016 - Wiley Online Library
Combination antiretroviral therapy (cART) effectively suppresses viral load in HIV‐infected
individuals, but it is not a cure. Bone marrow transplants using HIV‐resistant stem cells have …

Lymphomas in HIV-infected patients: literature review

AV Pivnik, MV Tumanova, NV Seregin… - Clinical …, 2014 - old.bloodjournal.ru
This review presents data on incidence, pathogenesis, diagnosis, and treatment of lymphoid
malignancies in HIV-infected patients. Articles published by Russian and foreign authors are …

APOBEC3G Role on HIV Infection in Africa: A Systematic Review

TR Compaore, AK Ouattara… - American Journal …, 2024 - archive.sdpublishers.com
The highly active antiretroviral treatment (HAART) has allowed people living with HIV to live
longer with a better quality of life. However, toxicity and the emergence of drug resistance …

The Role of BAALC-Expressing Leukemia Precursor Cells in the Pathogenesis of Myelodysplastic Syndromes

NN Mamaev, MV Latypova, AI Shakirova… - Clinical …, 2022 - old.bloodjournal.ru
The present paper provides evidence for a high detection rate of BAALC gene
overexpression, also combined with WT1 gene overexpression, in patients with …