Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

While macrophage phagocytosis is an immune defense mechanism against invading
cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel …

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) resistant to androgen
receptor signaling inhibitors (ARSI) is often lethal. Liquid biopsy biomarkers for this deadly …

Wnt (wingless-type) signaling pathway (WSP) alterations have been identified in patients
with prostate cancer and are implicated in disease progression and hormonal resistance. In …

Liver metastases from prostate cancer are associated with an aggressive disease course
and poor prognosis. Results from autopsy studies indicate a liver metastasis prevalence of …

Cancer is an aberrant growth of cells with dynamic molecular changes as the disease
progresses. As a result of these dynamic changes and an increase in cellular plasticity …

Background: Prostate cancer is a heterogenous disease, but once it becomes metastatic it
eventually becomes treatment resistant. One mechanism of resistance to AR-targeting …

Robust characterization of cellular phenotypes from single-cell gene expression data is of
paramount importance in studying complex biological systems and diseases. Single-cell …

Introduction: Our work addresses a literature review conducted between January 2019 and
September 2023, the importance of BRCA1, BRCA2, AR and PTEN genes in the …