Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to
what extent vancomycin is directly responsible, as numerous potential risk factors for acute …

Acute kidney injury is a common complication in critically ill patients with sepsis and/or
septic shock. Further, some essential antimicrobial treatment drugs are themselves …

Methods These are the consensus statements and guideline of ASHP, IDSA, the Pediatric
Infectious Diseases Society (PIDS), and SIDP. Guideline panel composition consisted of …

The electrochemical aptamer-based (E-AB) sensing platform appears to be a convenient
(rapid, single-step, and calibration-free) and modular approach to measure concentrations …

Background This study analyzed the relationship between vancomycin area under the
concentration-time curve (AUC) and acute kidney injury (AKI) reported across recent studies …

Evidence supports vancomycin therapeutic-drug monitoring by area under the concentration-
time curve (AUC), but data to establish an AUC upper limit are limited and published …

Vancomycin is a recommended therapy in multiple national guidelines. Despite the common
use, there is a poor understanding of the mechanistic drivers and potential modifiers of …

Drug-induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in
hospitalized patients and is associated with increased morbidity and mortality in both …

Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is
known to improve patient outcomes compared with fixed or empirical dosing strategies …

Clinical studies have reported additive nephrotoxicity associated with the combination of
vancomycin (VAN) and piperacillin-tazobactam (TZP). This study assessed differences in …