Epigenetic aging of mammalian gametes
M Klutstein, N Gonen - Molecular Reproduction and …, 2023 - Wiley Online Library
The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …
Epigenetic programming in the ovarian reserve
M Hu, RM Schultz, SH Namekawa - BioEssays, 2023 - Wiley Online Library
The ovarian reserve defines female reproductive lifespan, which in humans spans decades.
The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic …
The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic …
[HTML][HTML] Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction
M Gao, T Zhang, T Chen, Z Chen, Z Zhu, Y Wen… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: Premature ovarian insufficiency (POI) is an accelerated reduction in ovarian
function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a …
function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a …
PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation
M Hu, YH Yeh, S Maezawa, T Nakagawa… - Nucleic acids …, 2024 - academic.oup.com
Spermatogonial stem cells functionality reside in the slow-cycling and heterogeneous
undifferentiated spermatogonia cell population. This pool of cells supports lifelong fertility in …
undifferentiated spermatogonia cell population. This pool of cells supports lifelong fertility in …
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
S Maezawa, M Yukawa, K Hasegawa… - Cell Death & …, 2023 - nature.com
Gonadal sex determination and differentiation are controlled by somatic support cells of
testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that …
testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that …
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes
E Aizawa, EA Ozonov, YK Kawamura… - The EMBO …, 2023 - embopress.org
Recent studies have reported the differentiation of pluripotent cells into oocytes in vitro.
However, the developmental competence of in vitro‐generated oocytes remains low. Here …
However, the developmental competence of in vitro‐generated oocytes remains low. Here …
Potential therapeutic options for premature ovarian insufficiency: experimental and clinical evidence
X Ding, S Lv, Z Guo, X Gong, C Wang, X Zhang… - Reproductive …, 2023 - Springer
Premature ovarian insufficiency (POI) is a condition in which a woman experiences
premature decline in ovarian function before the age of 40 years, manifested by menstrual …
premature decline in ovarian function before the age of 40 years, manifested by menstrual …
[HTML][HTML] Prenatal exposure to CB2 receptors agonist differentially impacts male and female germ cells via histone modification
A Zucchi, E Innocenzi, A Onorato, S Dolci… - Mechanisms of ageing …, 2023 - Elsevier
Cannabis use during pregnancy is increasing in the last few years potentially because of
decreased perception of the risk of harm. Regardless, recent evidence demonstrated that …
decreased perception of the risk of harm. Regardless, recent evidence demonstrated that …
Epigenetic modifications of gonadotropin receptors can regulate follicular development
Y Yang, W Feng, J Zhou, R Zhang, X Lin… - Animal Reproduction …, 2024 - Elsevier
The spatiotemporal transcription of follicle-stimulating hormone receptor (FSHR) and
luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) are crucial events for …
luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) are crucial events for …
Mechanism study of YangJing ZhongYu decoction on regulating mitochondrial dynamics of ovarian granular cells and improving diminished ovarian reserve
P Li, J Kuang - Journal of Ovarian Research, 2024 - Springer
Objective Diminished ovarian reserve (DOR) encompasses both reproductive and
endocrine disorders, resulting in a decline in female fertility. This paper explored the …
endocrine disorders, resulting in a decline in female fertility. This paper explored the …