Defining the relationship between hypertension, cognitive decline, and dementia: a review

KA Walker, MC Power, RF Gottesman - Current hypertension reports, 2017 - Springer
Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

[HTML][HTML] Biomarker modeling of Alzheimer's disease

CR Jack, DM Holtzman - Neuron, 2013 - cell.com
Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological
abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many …

Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change

J Oschwald, S Guye, F Liem, P Rast, S Willis… - Reviews in the …, 2019 - degruyter.com
Little is still known about the neuroanatomical substrates related to changes in specific
cognitive abilities in the course of healthy aging, and the existing evidence is predominantly …

The vascular depression hypothesis: mechanisms linking vascular disease with depression

WD Taylor, HJ Aizenstein, GS Alexopoulos - Molecular psychiatry, 2013 - nature.com
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

MRI of healthy brain aging: A review

ME MacDonald, GB Pike - NMR in Biomedicine, 2021 - Wiley Online Library
We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

[HTML][HTML] Longitudinal association between hippocampus atrophy and episodic-memory decline

T Gorbach, S Pudas, A Lundquist, G Orädd… - Neurobiology of …, 2017 - Elsevier
There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

Trajectories of brain aging in middle-aged and older adults: regional and individual differences

N Raz, P Ghisletta, KM Rodrigue, KM Kennedy… - Neuroimage, 2010 - Elsevier
The human brain changes with age. However, the rate and the trajectories of change vary
among the brain regions and among individuals, and the reasons for these differences are …

[HTML][HTML] Diffusion tensor imaging of cerebral white matter integrity in cognitive aging

DJ Madden, IJ Bennett, A Burzynska, GG Potter… - … et Biophysica Acta (BBA …, 2012 - Elsevier
In this article we review recent research on diffusion tensor imaging (DTI) of white matter
(WM) integrity and the implications for age-related differences in cognition. Neurobiological …

Impact of aging on the auditory system and related cognitive functions: a narrative review

DMP Jayakody, PL Friedland, RN Martins… - Frontiers in …, 2018 - frontiersin.org
Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects
approximately one-third of the world's population. The peripheral and central hearing …

Structural imaging measures of brain aging

SN Lockhart, C DeCarli - Neuropsychology review, 2014 - Springer
During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …