As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a
series of cellular functions. It has been found that autophagy is closely involved in the …

Necroptosis is crucially involved in severe cardiac pathological conditions. However,
whether necroptosis contributes to age‐related intolerance to ischemia/reperfusion (I/R) …

Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …

There is currently increased interest in the use of the antimalarial drugs chloroquine and
hydroxychloroquine for the treatment of other diseases, including cancer and viral infections …

The evidence of strong pathological associations between type 2 diabetes and Alzheimer's
disease (AD) has increased in recent years. Contrary to suggestions that anti-diabetes drugs …

Approximately 90% of male diabetes mellitus patients have varying degrees of testicular
dysfunction. The molecular mechanism underlying diabetes‐induced testicular damage has …

Cadmium-based quantum dots (QDs) have shown their values in disease diagnosis, cellular
and molecular tracking, small-animal imaging, and therapeutic drug delivery. However, the …

Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …