The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
H Xu, H Van Remmen - Skeletal Muscle, 2021 - Springer
As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …
Autophagy in cardiovascular aging
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …
promotes the structural and functional declines of both the heart and the blood circulation …
Diet-induced obesity impairs spermatogenesis: A potential role for autophagy
Y Mu, W Yan, T Yin, Y Zhang, J Li, J Yang - Scientific reports, 2017 - nature.com
Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a
series of cellular functions. It has been found that autophagy is closely involved in the …
series of cellular functions. It has been found that autophagy is closely involved in the …
Metformin mediates cardioprotection against aging‐induced ischemic necroptosis
C Li, N Mu, C Gu, M Liu, Z Yang, Y Yin, M Chen… - Aging cell, 2020 - Wiley Online Library
Necroptosis is crucially involved in severe cardiac pathological conditions. However,
whether necroptosis contributes to age‐related intolerance to ischemia/reperfusion (I/R) …
whether necroptosis contributes to age‐related intolerance to ischemia/reperfusion (I/R) …
[HTML][HTML] Beyond its psychiatric use: the benefits of low-dose lithium supplementation
Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …
[HTML][HTML] Cardiac effects and toxicity of chloroquine: a short update
K Mubagwa - International Journal of Antimicrobial Agents, 2020 - Elsevier
There is currently increased interest in the use of the antimalarial drugs chloroquine and
hydroxychloroquine for the treatment of other diseases, including cancer and viral infections …
hydroxychloroquine for the treatment of other diseases, including cancer and viral infections …
Metformin facilitates amyloid-β generation by β-and γ-secretases via autophagy activation
SM Son, HJ Shin, J Byun, SY Kook… - Journal of …, 2016 - content.iospress.com
The evidence of strong pathological associations between type 2 diabetes and Alzheimer's
disease (AD) has increased in recent years. Contrary to suggestions that anti-diabetes drugs …
disease (AD) has increased in recent years. Contrary to suggestions that anti-diabetes drugs …
Metformin ameliorates testicular damage in male mice with streptozotocin‐induced type 1 diabetes through the PK2/PKR pathway
Y Liu, Z Yang, D Kong, Y Zhang… - Oxidative medicine and …, 2019 - Wiley Online Library
Approximately 90% of male diabetes mellitus patients have varying degrees of testicular
dysfunction. The molecular mechanism underlying diabetes‐induced testicular damage has …
dysfunction. The molecular mechanism underlying diabetes‐induced testicular damage has …
Inhibition of autophagy overcomes the nanotoxicity elicited by cadmium-based quantum dots
Cadmium-based quantum dots (QDs) have shown their values in disease diagnosis, cellular
and molecular tracking, small-animal imaging, and therapeutic drug delivery. However, the …
and molecular tracking, small-animal imaging, and therapeutic drug delivery. However, the …
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function
SI Hamstra, KC Whitley… - … of Physiology-Cell …, 2020 - journals.physiology.org
Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …