NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

[HTML][HTML] The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

MR Zinatizadeh, B Schock, GM Chalbatani, PK Zarandi… - Genes & diseases, 2021 - Elsevier
The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

NF-κB signaling in macrophages: dynamics, crosstalk, and signal integration

MG Dorrington, IDC Fraser - Frontiers in immunology, 2019 - frontiersin.org
The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

The non-canonical NF-κB pathway in immunity and inflammation

SC Sun - Nature reviews immunology, 2017 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

Signaling via the NFκB system

S Mitchell, J Vargas, A Hoffmann - … Reviews: Systems Biology …, 2016 - Wiley Online Library
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

N Arpaia, C Campbell, X Fan, S Dikiy… - Nature, 2013 - nature.com
Intestinal microbes provide multicellular hosts with nutrients and confer resistance to
infection. The delicate balance between pro-and anti-inflammatory mechanisms, essential …

Regulation of NF-κB by TNF family cytokines

MS Hayden, S Ghosh - Seminars in immunology, 2014 - Elsevier
The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …

Butyrate shapes immune cell fate and function in allergic asthma

W Yip, MR Hughes, Y Li, A Cait, M Hirst… - Frontiers in …, 2021 - frontiersin.org
The microbiome plays a fundamental role in how the immune system develops and how
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …

Emerging functions of regulatory T cells in tissue homeostasis

A Sharma, D Rudra - Frontiers in immunology, 2018 - frontiersin.org
CD4+ Foxp3+ regulatory T-cells (Tregs) are a unique subset of helper T-cells, which
regulate immune response and establish peripheral tolerance. Tregs not only maintain the …

Noncanonical NF-κB signaling in health and disease

G Cildir, KC Low, V Tergaonkar - Trends in molecular medicine, 2016 - cell.com
Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …