Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications

D Resiere, H Mehdaoui, R Neviere - Toxins, 2022 - mdpi.com
Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …

[HTML][HTML] Polymorphonuclear neutrophil leukocytes in snakebite envenoming

JP Zuliani, AM Soares, JM Gutiérrez - Toxicon, 2020 - Elsevier
Polymorphonuclear neutrophils are the most abundant leukocytes in the blood and
constitute key components of the innate immunity. Upon infection or tissue damage …

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

RR Senji Laxme, S Khochare, S Attarde… - PLoS neglected …, 2021 - journals.plos.org
Background Snakebite in India results in over 58,000 fatalities and a vast number of
morbidities annually. The majority of these clinically severe envenomings are attributed to …

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …

Fangs in the Ghats: preclinical insights into the medical importance of pit vipers from the Western Ghats

S Khochare, RR Senji Laxme, P Jaikumar… - International Journal of …, 2023 - mdpi.com
The socioeconomic impact of snakebites in India is largely attributed to a subset of snake
species commonly known as the 'big four'. However, envenoming by a range of other …

Remarkable intrapopulation venom variability in the monocellate cobra (Naja kaouthia) unveils neglected aspects of India's snakebite problem

U Rashmi, S Khochare, S Attarde, RRS Laxme… - Journal of …, 2021 - Elsevier
Interpopulation venom variation has been widely documented in snakes across large
geographical distances. This variability is known to markedly influence the effectiveness of …

Diacetoxyscirpenol-induced heterophil extracellular traps contribute to the immune toxicity of liver injury in chickens

D Wu, S Li, P Li, A Jiang, Z Liu, Y Zhang, J Wang… - Food and Chemical …, 2021 - Elsevier
Diacetoxyscirpenol (DAS) is one kind of type A trichothecene mycotoxin which produced by
Fusarium species which contaminates agricultural crops and food. DAS attracts particular …

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

C Li, C Wu, F Li, W Xu, X Zhang… - Journal of Inflammation …, 2024 - Taylor & Francis
Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation
due to the deposition of monosodium urate (MSU) crystals in the joints. The …

Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK1/2 and P38 signalling pathways, glycolysis and autophagy in chickens

M Chen, Z Jin, Q Jin, W Liu, X Gao, H Hong… - Parasite …, 2023 - Wiley Online Library
Toxoplasma gondii is a zoonotic parasite with a global distribution. Heterophil extracellular
traps (HETs) are a novel innate immune mechanism of chickens against pathogens, but …

[HTML][HTML] Effects of venoms on neutrophil respiratory burst: a major inflammatory function

J El-Benna, M Hurtado-Nedelec… - Journal of Venomous …, 2021 - SciELO Brasil
Neutrophils play a pivotal role in innate immunity and in the inflammatory response.
Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the …