Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing

VA López-Agudelo, D Gómez-Ríos, H Ramirez-Malule - Antibiotics, 2021 - mdpi.com
Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak
antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically …

Production of β-Lactamase Inhibitors by Streptomyces Species

DA Viana Marques, SEF Machado, VCS Ebinuma… - Antibiotics, 2018 - mdpi.com
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of
resistance against β-lactam antibiotics. The Streptomyces genus is known for being an …

Liquid–liquid extraction by mixed micellar systems: a new approach for clavulanic acid recovery from fermented broth

VC Santos, FA Hasmann, A Converti… - Biochemical Engineering …, 2011 - Elsevier
This work is the first attempt to apply aqueous two-phase mixed micellar systems (ATPMS) of
the nonionic surfactant Triton X-114 and the anionic one AOT to extract clavulanic acid (CA) …

Separation of azadirachtin and other limonoids from crude neem oil via solvent precipitation

E Melwita, YH Ju - Separation and Purification Technology, 2010 - Elsevier
Separation of azadirachtin and other limonoids from neem oil was carried out using solvent
induced precipitation method. Hexane was chosen as the solvent due to its low polarity that …

Purification of clavulanic acid produced by Streptomyces clavuligerus via submerged fermentation using polyethylene glycol/cholinium chloride aqueous two-phase …

P Panas, C Lopes, MO Cerri, SPM Ventura… - Fluid Phase …, 2017 - Elsevier
Clavulanic acid (CA) is an important pharmaceutical compound produced by batch
fermentation of Streptomyces clavuligerus. Since, CA is chemically unstable, its downstream …

Extractive fermentation of clavulanic acid by Streptomyces DAUFPE 3060 using aqueous two‐phase system

DA Viana Marques, A Pessoa‐Júnior… - Biotechnology …, 2011 - Wiley Online Library
The influence of four variables, specifically PEG molar mass (400, 1,000, and 8,000 g/mol),
concentrations of PEG and phosphate salts (15, 20, and 25% for both), and agitation …

In situ phenol removal from fed-batch fermentations of solvent tolerant Pseudomonas putida S12 by pertraction

L Heerema, N Wierckx, M Roelands… - Biochemical …, 2011 - Elsevier
In situ phenol pertraction with 1-octanol has been experimentally studied to improve the
production of the model component phenol by a recombinant strain of Pseudomonas putida …

Clavulanic acid partitioning in charged aqueous two-phase micellar systems

RB Haga, VC Santos-Ebinuma, MSC Silva… - Separation and …, 2013 - Elsevier
Clavulanic acid is a drug obtained by Streptomyces sp. Fermentation and therapeutically
employed in association with β-lactamic antibiotics to avoid bacterial resistance. Its industrial …

[PDF][PDF] Inhibition of beta-lactamase enzyme of Pseudomonas eruginosa by clavulanic acid of Rumex vesicarius L

AA Al-Sahli, WM Abdulkhair - African Journal of Agricultural …, 2011 - academicjournals.org
Pseudomonas aeruginosa possesses beta-lactams resistance machinery by secretion of
extracellular beta-lactamase enzyme. The present study was begun with collection of eighty …

In-situ product removal from fermentations by membrane extraction: Conceptual process design and economics

L Heerema, M Roelands, E Goetheer… - Industrial & …, 2011 - ACS Publications
This paper describes a conceptual process design for the production of the model
component phenol by a recombinant strain of the micro-organism Pseudomonas putida S12 …