Strategies based on organ decellularization and recellularization
KH Hillebrandt, H Everwien, N Haep… - Transplant …, 2019 - Wiley Online Library
Transplantation is the only curative treatment option available for patients suffering from end‐
stage organ failure, improving their quality of life and long‐term survival. However, because …
stage organ failure, improving their quality of life and long‐term survival. However, because …
Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application
J Yang, H Dang, Y Xu - Artificial organs, 2022 - Wiley Online Library
Background Decellularized extracellular matrixs (dECMs) derived from organs and tissues
have emerged as a promising tool, as they encompass the characteristics of an ideal tissue …
have emerged as a promising tool, as they encompass the characteristics of an ideal tissue …
Engineering pulmonary vasculature in decellularized rat and human lungs
Bioengineered lungs produced from patient-derived cells may one day provide an
alternative to donor lungs for transplantation therapy. Here we report the regeneration of …
alternative to donor lungs for transplantation therapy. Here we report the regeneration of …
Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds
JS Uzarski, MD DiVito, JA Wertheim, WM Miller - Biomaterials, 2017 - Elsevier
Precise measurement of cellularity within bioartificial tissues and extracellular matrix (ECM)
scaffolds is necessary to augment rigorous characterization of cellular behavior, as accurate …
scaffolds is necessary to augment rigorous characterization of cellular behavior, as accurate …
Bioengineering human lung grafts on porcine matrix
Objective: Bioengineering of viable, functional, and implantable human lung grafts on
porcine matrix. Summary Background Data: Implantable bioartificial organ grafts could …
porcine matrix. Summary Background Data: Implantable bioartificial organ grafts could …
Human-scale lung regeneration based on decellularized matrix scaffolds as a biologic platform
K Ohata, HC Ott - Surgery today, 2020 - Springer
Lung transplantation is currently the only curative treatment for patients with end-stage lung
disease; however, donor organ shortage and the need for intense immunosuppression limit …
disease; however, donor organ shortage and the need for intense immunosuppression limit …
Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain
Engineering of functional vascularized liver tissues holds great promise in addressing donor
organ shortage for transplantation. Whole organ decellularization is a cell removal method …
organ shortage for transplantation. Whole organ decellularization is a cell removal method …
Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment
M Stadler, S Walter, A Walzl, N Kramer, C Unger… - Seminars in cancer …, 2015 - Elsevier
Solid cancers are not simple accumulations of malignant tumor cells but rather represent
complex organ-like structures. Despite a more chaotic general appearance as compared to …
complex organ-like structures. Despite a more chaotic general appearance as compared to …
Regenerative potential of human airway stem cells in lung epithelial engineering
Bio-engineered organs for transplantation may ultimately provide a personalized solution for
end-stage organ failure, without the risk of rejection. Building upon the process of whole …
end-stage organ failure, without the risk of rejection. Building upon the process of whole …
Lung microvascular niche, repair, and engineering
T Tsuchiya, R Doi, T Obata, G Hatachi… - … in Bioengineering and …, 2020 - frontiersin.org
Biomaterials have been used for a long time in the field of medicine. Since the success of
“tissue engineering” pioneered by Langer and Vacanti in 1993, tissue engineering studies …
“tissue engineering” pioneered by Langer and Vacanti in 1993, tissue engineering studies …