Modifications in mRNA constitute ancient mechanisms to regulate gene expression post-
transcriptionally. N 6-methyladenosine (m 6 A) is the most prominent mRNA modification …

In the last years it has become increasingly clear that the mammalian transcriptome is highly
complex and includes a large number of small non-coding RNAs (sncRNAs) and long …

Objective—Cardiovascular disease caused by atherosclerosis is the number one cause of
death in Western countries and threatens to become the major cause of morbidity and …

Objective miR-21 is an oncomir highly upregulated in hepatocellular carcinoma and in early
stages of liver diseases characterised by the presence of steatosis. Whether upregulation of …

Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive
properties and is widely used for treating autoimmune and inflammatory diseases such as …

Skeletal muscle atrophy is prevalent in chronic diseases, and microRNAs (miRs) may play a
key role in the wasting process. miR-23a was previously shown to inhibit the expression of …

Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the
people with diabetes, with approximately 80% of the deaths in diabetics are due to …

C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non‐coding
RNAs that have been long known to perform 2′‐O‐methylation of rRNAs. However …

The bioactivation of pro-toxicants is the biological process through which some chemicals
are metabolized into reactive metabolites. Therefore, in vitro toxicological evaluation should …

Background MicroRNAs in solid malignancies can behave as predictors of either good or
poor outcome. This is the case with members of the miR-200 family, which are the primary …