A new discipline of “systems chemistry” is emerging, which aims to capture the complexity
observed in natural systems within a synthetic chemical framework. Living systems rely on …

The molecular events underlying many human hereditary disorders remain to be discovered
despite the significant advances made in molecular biology and genetics in the past years …

We consider the problem of assessing structural stability of biochemical reaction networks
with monotone reaction rates, namely of establishing if all the networks with a certain …

The engineering of transcriptional networks presents many challenges due to the inherent
uncertainty in the system structure, changing cellular context, and stochasticity in the …

It has recently been shown that structural conditions on the reaction network, rather than a
'fine-tuning'of system parameters, often suffice to impart 'absolute concentration …

Many science phenomena are described as interacting particle systems (IPS). The mean
field limit (MFL) of large all-to-all coupled deterministic IPS is given by the solution of a PDE …

Feedback control has enabled the success of automated technologies by mitigating the
effects of variability, unknown disturbances, and noise. While it is known that biological …

We consider the problem of identifying structural influences of external inputs on steady-
state outputs in a biological network model. We speak of a structural influence if, upon a …

Despite their complexity, biological systems are able to endure huge parameter fluctuations
and survive in the most diverse environmental conditions. Mathematical tools from graph …

For a vast class of dynamical networks, including chemical reaction networks (CRNs) with
monotonic reaction rates, the existence of a polyhedral Lyapunov function (PLF) implies …