Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
SJ Kaar, S Natesan, R Mccutcheon, OD Howes - Neuropharmacology, 2020 - Elsevier
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …
disorders but are ineffective for some patients and associated with side-effects and …
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
SEP-363856, a novel psychotropic agent with a unique, non-D2 receptor mechanism of action
N Dedic, PG Jones, SC Hopkins, R Lew, L Shao… - … of Pharmacology and …, 2019 - ASPET
For the past 50 years, the clinical efficacy of antipsychotic medications has relied on
blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to …
blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to …
A test of the transdiagnostic dopamine hypothesis of psychosis using positron emission tomographic imaging in bipolar affective disorder and schizophrenia
Importance The dopamine hypothesis suggests that dopamine abnormalities underlie
psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective …
psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective …
Determinants of treatment response in first-episode psychosis: an 18F-DOPA PET study
Psychotic illnesses show variable responses to treatment. Determining the neurobiology
underlying this is important for precision medicine and the development of better treatments …
underlying this is important for precision medicine and the development of better treatments …
The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy …
Background The pathophysiology of psychosis is incompletely understood. Disruption in
cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a …
cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a …
A potential biomarker for treatment stratification in psychosis: evaluation of an [18F] FDOPA PET imaging approach
M Veronese, B Santangelo, S Jauhar… - …, 2021 - nature.com
Abstract [18F] FDOPA PET imaging has shown dopaminergic function indexed as K icer
differs between antipsychotic treatment responders and non-responders. However, the …
differs between antipsychotic treatment responders and non-responders. However, the …
Striatal dopamine and reward prediction error signaling in unmedicated schizophrenia patients
Increased striatal dopamine synthesis capacity has consistently been reported in patients
with schizophrenia. However, the mechanism translating this into behavior and symptoms …
with schizophrenia. However, the mechanism translating this into behavior and symptoms …