[HTML][HTML] Hydroxylases involved in terpenoid biosynthesis: a review
Z Zhang, QY Wu, Y Ge, ZY Huang, R Hong, A Li… - Bioresources and …, 2023 - Springer
Terpenoids are pervasive in nature and display an immense structural diversity. As the
largest category of plant secondary metabolites, terpenoids have important socioeconomic …
largest category of plant secondary metabolites, terpenoids have important socioeconomic …
Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III
B Jiang, L Gao, H Wang, Y Sun, X Zhang, H Ke, S Liu… - Science, 2024 - science.org
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a
highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly …
highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly …
[HTML][HTML] Recent advances in metabolic engineering, protein engineering, and transcriptome-guided insights toward synthetic production of taxol
I Mutanda, J Li, F Xu, Y Wang - Frontiers in bioengineering and …, 2021 - frontiersin.org
The diterpenoid paclitaxel (Taxol®) is a blockbuster anticancer agent that was originally
isolated from the Pacific yew (Taxus brevifolia) five decades ago. Despite the wealth of …
isolated from the Pacific yew (Taxus brevifolia) five decades ago. Despite the wealth of …
[HTML][HTML] Reconstitution of early paclitaxel biosynthetic network
JCT Liu, R De La Peña, C Tocol, ES Sattely - Nature Communications, 2024 - nature.com
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades,
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …
Unraveling the catalytic mechanism of taxadiene-5α-hydroxylase from crystallography and computational analyses
X Song, Q Wang, X Zhu, W Fang, X Liu, C Shi… - ACS …, 2024 - ACS Publications
Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …
Optimizing the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
LE Walls, K Malcı, B Nowrouzi, RA Li… - Biotechnology and …, 2021 - Wiley Online Library
Taxadien‐5α‐hydroxylase and taxadien‐5α‐ol O‐acetyltransferase catalyze the oxidation of
taxadiene to taxadien‐5α‐ol and subsequent acetylation to taxadien‐5α‐yl‐acetate in the …
taxadiene to taxadien‐5α‐ol and subsequent acetylation to taxadien‐5α‐yl‐acetate in the …
The chemistry of nonclassical taxane diterpene
F Schneider, L Pan, M Ottenbruch, T List… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus The taxane diterpenes are a pharmaceutically vital family of natural products,
consisting of more than 550 congeners. All taxane diterpenes are isolated from slow …
consisting of more than 550 congeners. All taxane diterpenes are isolated from slow …
Taxol® Biosynthesis and Production: From Forests to Fermenters
C McElroy, S Jennewein - Biotechnology of natural products, 2018 - Springer
Taxol®(paclitaxel) has fascinated researchers, medical professionals, politicians and
entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer …
entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer …
Engineering of taxadiene synthase for improved selectivity and yield of a key taxol biosynthetic intermediate
Attempts at microbial production of the chemotherapeutic agent Taxol (paclitaxel) have met
with limited success, due largely to a pathway bottleneck resulting from poor product …
with limited success, due largely to a pathway bottleneck resulting from poor product …
Biosynthesis of paclitaxel using synthetic biology
Y Tong, YF Luo, W Gao - Phytochemistry Reviews, 2021 - Springer
Paclitaxel is a tricyclic diterpenoid first isolated from the bark of Taxus brevifolia. It is notably
one of the most effective natural anticancer drugs discovered so far, and has been widely …
one of the most effective natural anticancer drugs discovered so far, and has been widely …