Terpenoids are pervasive in nature and display an immense structural diversity. As the
largest category of plant secondary metabolites, terpenoids have important socioeconomic …

Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a
highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly …

The diterpenoid paclitaxel (Taxol®) is a blockbuster anticancer agent that was originally
isolated from the Pacific yew (Taxus brevifolia) five decades ago. Despite the wealth of …

Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades,
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …

Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …

Taxadien‐5α‐hydroxylase and taxadien‐5α‐ol O‐acetyltransferase catalyze the oxidation of
taxadiene to taxadien‐5α‐ol and subsequent acetylation to taxadien‐5α‐yl‐acetate in the …

Conspectus The taxane diterpenes are a pharmaceutically vital family of natural products,
consisting of more than 550 congeners. All taxane diterpenes are isolated from slow …

Taxol®(paclitaxel) has fascinated researchers, medical professionals, politicians and
entrepreneurs for almost half a century. Its medicinal value as a potent anti-cancer …

Attempts at microbial production of the chemotherapeutic agent Taxol (paclitaxel) have met
with limited success, due largely to a pathway bottleneck resulting from poor product …

Paclitaxel is a tricyclic diterpenoid first isolated from the bark of Taxus brevifolia. It is notably
one of the most effective natural anticancer drugs discovered so far, and has been widely …