Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
BCL-2 protein family: attractive targets for cancer therapy
D Kaloni, ST Diepstraten, A Strasser, GL Kelly - Apoptosis, 2023 - Springer
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
[HTML][HTML] Efficacy of PI3K inhibitors in advanced breast cancer
B Verret, J Cortes, T Bachelot, F Andre, M Arnedos - Annals of Oncology, 2019 - Elsevier
Abstract The phosphoinositide 3 (PI3)-kinase/Akt signaling pathway has always been a
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
Targeting PI3K/Akt/mTOR in AML: rationale and clinical evidence
S Darici, H Alkhaldi, G Horne, HG Jørgensen… - Journal of Clinical …, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …
Development of PI3K inhibitors: Advances in clinical trials and new strategies
D Meng, W He, Y Zhang, Z Liang, J Zheng… - Pharmacological …, 2021 - Elsevier
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are the family of vital lipid kinases widely
distributed in mammalian cells. The overexpression of PI3Ks leads to hyperactivation of the …
distributed in mammalian cells. The overexpression of PI3Ks leads to hyperactivation of the …
Mechanisms of resistance to PI3K inhibitors in cancer: adaptive responses, drug tolerance and cellular plasticity
Simple Summary The phosphoinositide-3-kinase (PI3K) pathway is the most frequently
activated pathway in human cancers. Consequently, a number of compounds targeting the …
activated pathway in human cancers. Consequently, a number of compounds targeting the …
The Magic Methyl and Its Tricks in Drug Discovery and Development
One of the key scientific aspects of small-molecule drug discovery and development is the
analysis of the relationship between its chemical structure and biological activity …
analysis of the relationship between its chemical structure and biological activity …