SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact

M Lipsitch, F Krammer, G Regev-Yochay… - Nature Reviews …, 2022 - nature.com
Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) in fully vaccinated individuals are receiving intense scrutiny because of their importance …

Prevention of host-to-host transmission by SARS-CoV-2 vaccines

D Mostaghimi, CN Valdez, HT Larson… - The Lancet infectious …, 2022 - thelancet.com
As the number of individuals vaccinated against SARS-CoV-2 rises worldwide, population-
level data regarding the vaccines' ability to reduce infection are being generated …

Mucosal plasma cells are required to protect the upper airway and brain from infection

SA Wellford, AP Moseman, K Dao, KE Wright, A Chen… - Immunity, 2022 - cell.com
While blood antibodies mediate protective immunity in most organs, whether they protect
nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice …

[HTML][HTML] Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

S Sureshchandra, SA Lewis, BM Doratt, A Jankeel… - JCI insight, 2021 - ncbi.nlm.nih.gov
Abstract mRNA vaccines for SARS-CoV-2 have shown exceptional clinical efficacy,
providing robust protection against severe disease. However, our understanding of …

Guardians of the oral and nasopharyngeal galaxy: IgA and protection against SARS‐CoV‐2 infection

S Sheikh‐Mohamed, EC Sanders… - Immunological …, 2022 - Wiley Online Library
In early 2020, a global emergency was upon us in the form of the coronavirus disease 2019
(COVID‐19) pandemic. While horrific in its health, social and economic devastation, one …

[HTML][HTML] Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination

J Goncalves, AM Juliano, N Charepe, M Alenquer… - Cell Reports …, 2021 - cell.com
In view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and
mRNA-1273 vaccines affect the immune response in lactating women and the protective …

Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers

KT Abe, Q Hu, M Mozafarihashjin, R Samson… - medRxiv, 2021 - medrxiv.org
Prioritizing Ontario's long-term care home (LTCH) residents for vaccination against severe
acute respiratory syndrome coronavirus 2 has drastically reduced their disease burden; …

Characterization of serum and mucosal SARS-CoV-2-antibodies in HIV-1-infected subjects after BNT162b2 mRNA vaccination or SARS-CoV-2 infection

KG Schmidt, EG Harrer, K Tascilar, S Kübel, B El Kenz… - Viruses, 2022 - mdpi.com
Only limited data are available regarding the immunogenicity of the BNT162b2 mRNA
vaccine in HIV-1+ patients. Therefore, we investigated the humoral immune response after …

Efficient mucosal antibody response to SARS-CoV-2 vaccination is induced in previously infected individuals

K Sano, D Bhavsar, G Singh, D Floda, K Srivastava… - MedRxiv, 2021 - medrxiv.org
Mucosal immune responses are critical to prevent respiratory infections but it is unclear to
what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA …

[HTML][HTML] Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern

E Lafon, M Jäger, A Bauer, M Reindl… - Journal of allergy and …, 2022 - Elsevier
Background Few studies have directly compared virus-specific antibodies and their
neutralizing capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV …