During an ST-elevation myocardial infarction (STEMI), the myocardium undergoes a
prolonged period of ischaemia. Reperfusion therapy is essential to minimize cardiac injury …

Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation
that are required for hemostasis. However, aberrant activation of coagulation can lead to …

Despite major advances in acute interventions for myocardial infarction (MI), adverse
cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain …

BACKGROUND: SR-B1 (scavenger receptor class B type 1)/LDLR (low-density lipoprotein
receptor) double knockout mice fed a high-fat, high-cholesterol diet containing cholate …

The influenza A virus (IAV) causes a respiratory tract infection with approximately 10% of the
population infected by the virus each year. Severe IAV infection is characterized by …

Platelets are important actors of cardiovascular diseases (CVD). Current antiplatelet drugs
that inhibit platelet aggregation have been shown to be effective in CVD treatment. However …

Anthracycline antineoplastic agents such as doxorubicin are widely used and highly
effective component of adjuvant chemotherapy for breast cancer and curative regimens for …

Rationale: While thrombin is the key protease in thrombus formation, other coagulation
proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate …

Background: Platelets are major players of thrombosis and inflammation after acute
myocardial infarction (AMI). The impact of thrombocytopenia on platelet-induced cellular …

Adult hearts are hard to recover after cardiac injury due to the limited proliferative ability of
cardiomyocytes. Emerging evidence indicates the induction of cell cycle reentry of …