Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …

As the demographic structure shifts towards an aging society, strategies aimed at slowing
down or reversing the aging process become increasingly essential. Aging is a major …

Molecular information on the early stages of human retinal development remains scarce due
to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal …

RNA splicing shapes the gene regulatory programs that underlie various physiological and
disease processes. Here, we present the SCASL (single-cell clustering based on alternative …

With an increase in accuracy and throughput of long-read sequencing technologies, they
are rapidly being assimilated into the single-cell sequencing pipelines. For transcriptome …

Problem Preeclampsia (PE) and fetal growth restriction (FGR) are often associated with
maternal inflammation and an increased risk of cardiovascular and metabolic disease in the …

Deciphering spatial domains using spatially resolved transcriptomics (SRT) is of great value
for the characterizing and understanding of tissue architecture. However, the inherent …

Bruton's tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …

Alternative splicing has long been recognized as a powerful tool to expand the diversity of
the transcriptome and the proteome. The study of hematopoiesis, from hematopoietic stem …

Direct reprogramming of human fibroblasts into hematopoietic stem cells (HSCs) presents a
promising strategy for overcoming the limitations of traditional bone-marrow transplantation …