Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health

C Morisseau, BD Hammock - Annual review of pharmacology …, 2013 - annualreviews.org
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

KM Wagner, CB McReynolds, WK Schmidt… - Pharmacology & …, 2017 - Elsevier
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs

A Sadri - Journal of medicinal chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

[HTML][HTML] Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

JD Imig, BD Hammock - Nature reviews Drug discovery, 2009 - nature.com
The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

G Zhang, D Panigrahy, LM Mahakian… - Proceedings of the …, 2013 - National Acad Sciences
Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil)
reduce the risks of macular degeneration and cancers, but the mechanisms by which these …

Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products

CP Sun, XY Zhang, C Morisseau… - Journal of medicinal …, 2020 - ACS Publications
Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications

HC Shen, BD Hammock - Journal of medicinal chemistry, 2012 - ACS Publications
1. INTRODUCTION Epoxide hydrolases have been detected in prokaryotes and eukaryotes
ranging from plants to mammals. 1− 3 In mammals these include the soluble epoxide …

Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

G Zhang, S Kodani, BD Hammock - Progress in lipid research, 2014 - Elsevier
Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …

1-Aryl-3-(1-acylpiperidin-4-yl) urea inhibitors of human and murine soluble epoxide hydrolase: Structure− activity relationships, pharmacokinetics, and reduction of …

TE Rose, C Morisseau, JY Liu, B Inceoglu… - Journal of medicinal …, 2010 - ACS Publications
1, 3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate
their structure− activity relationships as inhibitors of the human and murine soluble epoxide …

Synthesis and biological evaluation of sorafenib-and regorafenib-like sEH inhibitors

SH Hwang, AT Wecksler, G Zhang, C Morisseau… - Bioorganic & medicinal …, 2013 - Elsevier
To reduce the pro-angiogenic effects of sEH inhibition, a structure–activity relationship
(SAR) study was performed by incorporating structural features of the anti-angiogenic multi …