Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Next-generation sequencing has enhanced discovery of many disease-associated genes in
previously unexplained epilepsies, mainly in developmental and epileptic encephalopathies …

Two decades of research have proven the relevance of ion channel expression for tumor
progression in virtually every indication, and it has become clear that inhibition of specific …

Antiepileptic drugs have been successfully treating epilepsy and providing individuals
sustained seizure freedom. However, about 30% of the patients with epilepsy present drug …

Epilepsy is characterised by spontaneous recurrent seizures that are caused by an
imbalance between neuronal excitability and inhibition. Since ion channels play …

Potassium channels are a heterogeneous group of membrane-bound proteins, whose
functions support a diverse range of biological processes. Genetic disorders arising from …

Inhibition of T-type calcium channels (CaV3) prevents development of diseases related to
cardiovascular and nerve systems. Further, knockout animal studies have revealed that …

Simple Summary A novel structural class of inhibitors of the voltage-gated potassium
channel KV10. 1 was discovered by a ligand-based drug design method using a 3D …

The expression and function of many ion channels and transporters in cancer cells display
major differences in comparison to those from healthy cells. These differences provide the …

Assassin bugs are venomous insects that prey on other arthropods. Their venom has lethal,
paralytic, and liquifying effects when injected into prey, but the toxins responsible for these …