Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease

P Hegyi, J Maléth, JR Walters… - Physiological …, 2018 - journals.physiology.org
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

Tauroursodeoxycholate—bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives

M Kusaczuk - Cells, 2019 - mdpi.com
Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon

JBJ Ward, NK Lajczak, OB Kelly… - American Journal …, 2017 - journals.physiology.org
Inflammatory bowel diseases (IBD) comprise a group of common and debilitating chronic
intestinal disorders for which currently available therapies are often unsatisfactory. The …

From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across …

F Huang, CM Pariante, A Borsini - Brain, behavior, and immunity, 2022 - Elsevier
Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …

[HTML][HTML] Recent advances on FXR-targeting therapeutics

K Panzitt, G Zollner, HU Marschall, M Wagner - Molecular and cellular …, 2022 - Elsevier
The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic
and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD). FXR is …

Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns

ML Coghlan, J Haile, J Houston, DC Murray… - PLoS …, 2012 - journals.plos.org
Traditional Chinese medicine (TCM) has been practiced for thousands of years, but only
within the last few decades has its use become more widespread outside of Asia. Concerns …

Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy

JF Goossens, C Bailly - Pharmacology & therapeutics, 2019 - Elsevier
Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of
(cheno) deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal …

Human-wildlife conflicts influence attitudes but not necessarily behaviors: Factors driving the poaching of bears in China

F Liu, WJ McShea, DL Garshelis, X Zhu, D Wang… - Biological …, 2011 - Elsevier
Human-wildlife conflicts often spur retaliatory killing, which may be a major threat to some
wildlife species. Asiatic black bears depredate crops and livestock and also attack humans …

Taking a more nuanced look at behavior change for demand reduction in the illegal wildlife trade

L Thomas‐Walters, D Veríssimo… - … Science and Practice, 2020 - Wiley Online Library
The illegal wildlife trade threatens the future of many species, and undermines economies
and livelihoods. Conservationists have largely responded with supply‐side interventions …

[HTML][HTML] Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review

F Tonin, IWCE Arends - Beilstein journal of organic chemistry, 2018 - beilstein-journals.org
Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile
acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic …