The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Because life is often unpredictable, dynamic, and complex, all animals have evolved
remarkable abilities to cope with changes in their external environment and internal …

In response to harsh environmental conditions, C. eleganslarvae undergo dauer arrest at
the second molt. The past decade has yielded many insights into the signaling pathways …

The human hypoxia-inducible transcription factor HIF-1 is a critical regulator of cellular and
systemic responses to low oxygen levels. When oxygen levels are high, the HIF-1α subunit …

The human genome encodes 10 insulin-like genes, whereas the Caenorhabditis elegans
genome remarkably encodes 40 insulin-like genes. Knockout strategies to determine the …

Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic
hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A key step in …

In the model organism Caenorhabditis elegans, the dauer pheromone is the primary cue for
entry into the developmentally arrested, dauer larval stage. The dauer is specialized for …

Rab small GTPases are involved in the transport of vesicles between different membranous
organelles. RAB-3 is an exocytic Rab that plays a modulatory role in synaptic transmission …

Diapause is a state of developmental arrest adopted in response to or in anticipation of
environmental conditions that are unfavorable for growth. In many cases, diapause is …