Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …

Melatonin is a highly conserved molecule. Its presence can be traced back to ancient
photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a …

Melatonin has been shown to protect against oxidative stress in various, highly divergent
experimental systems. There are many reasons for its remarkable protective potential …

Kynuramines represent their own class of biogenic amines. They are formed either by
decarboxylation of kynurenines or pyrrole ring cleavage of indoleamines. N2‐formylated …

Melatonin, originally discovered as a hormone of the pineal gland, is also produced in other
organs and represents, additionally, a normal food constituent found in yeast and plant …

Melatonin had previously been shown to reduce up to four 2, 2 '‐azino‐bis‐(3‐
ethylbenzthiazoline‐6‐sulfonic acid) cation radicals (ABTS•+) via a scavenger cascade …

The metabolism of melatonin in the central nervous system is of interest for several reasons.
Melatonin enters the brain either via the pineal recess or by uptake from the blood. It has …

Improved survival from advances in neonatal care has resulted in an increased number of
infants at risk for chronic lung disease (CLD). Recently, it was reported that inflammatory …

Unlike animals, plants amply convert melatonin into 2-hydroxymelatonin (2-OHM) and cyclic
3-hydroxymelatonin (3-OHM) through the action of melatonin 2-hydroxylase (M2H) and …