The physiological evidence linking the production of superoxide, hydrogen peroxide, and
nitric oxide in the renal medullary thick ascending limb of Henle (mTAL) to regulation of …

Age-related macular degeneration (AMD) represents the leading cause of vision loss in the
elderly. Accumulation of lipid-and protein-rich deposits under the retinal pigment epithelium …

Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …

The renal medullary microcirculation is a distinctive arrangement of blood vessels that serve
multiple functions in the renal medulla. This article begins with a description of the unique …

Background: Medullary blood flow is via vasa recta capillaries, which possess contractile
pericytes. In vitro studies using isolated descending vasa recta show that pericytes can …

Publisher Summary This chapter focuses on the renal microcirculation. The microcirculation
of the kidney is particularly intriguing because optimum regulation of renal microcirculatory …

The contributions of angiotensin II type 1 (AT1) and type 2 (AT2) receptors to the control of
regional kidney blood flow were determined in pentobarbital-anesthetized rabbits …

Recent studies suggested that type 2 angiotensin receptor (AT2R) could contribute to
regulation of blood pressure and/or vascular remodeling. A key question relates to the …

The PDZ domain adaptor protein Na+/H+ exchanger regulatory factor (NHERF)-2 is
expressed in renal medullary descending vasa recta (DVR), although its function has not …

We have demonstrated previously that paracrine signaling occurs between medullary thick
ascending limb (mTAL) and the contractile pericytes of outer-medullary vasa recta (VR) …