Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

An ageing myocardium possesses significant electrophysiological alterations that
predisposes the elderly patient to arrhythmic risk. Whilst these alterations are intrinsic to the …

Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation,
supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the …

The mouse is the second mammalian species, after the human, in which substantial amount
of the genomic information has been analyzed. With advances in transgenic technology …

Brugada syndrome (BrS) is an inherited cardiac channelopathy first diagnosed in 1992 but
still considered a challenging disease in terms of diagnosis, arrhythmia risk prediction …

The recent COVID-19 pandemic highlights the need for rapid responses in developing
treatment strategies for new and emerging diseases. The option to repurpose drugs …

Cardiac arrhythmias cause significant morbidity and mortality and pose a major public
health problem. They arise from disruptions in the normally orderly propagation of cardiac …

Cardiac arrhythmias constitute a major public health problem. Pharmacological intervention
remains mainstay to their clinical management. This, in turn, depends upon systematic drug …

A letter to the editor in response to the article" Depolarization vs. repolarization: what is the
mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency …